The drug Motilium contains active ingridient Domperidone 10mg. It is ant-emitic, dopamine antagonist type of drug. Domperidone main purpose is to treat nausea and vomiting as well as fullness, abdominal bloating, fullness, and discomfort.
It blocks certain dopamine receptors in brain chemoreceptor trigger zone (CTZ). Its mechanism effectively blocks vomiting reflex and stops nausea.
Before taking this pill consult with your doctor. Be aware in case of following:
Any allergic reactions.
There were no studies of Domperidone use by pregnant women and children. Animal tests found no birth defects. No specific information exists about possible harm to children. Domperidone passes into the milk of breast-feeding women, but there is no information of possible negative effects. Make sure to consult your doctor before using Domperidone.
Also consult your doctor before taking this medicine if you have bleeding from stomach, bowel problems, liver disease.
Usual dose of domperidone is 10mg 3-4 times per day, 20-30 min before eat or before sleep. It can be increased to 20 mg 3-4 times a day.
Possible side effects
Long term use is not always recommended.
Lactose and not be suitable for people with intolerance to lactose. Side effects can include the following: breast pain, stomach cramps, diarrhoea, abnormal enlargement of breasts in men, abnormal movements of legs, hands, face, neck and tongue, eg tremor,twitching, rigidity (extrapyramidal effects).
Overdose symptoms can incluse disorientation, drowsiness and extrapyramidal reactions. In these situations anti-parkinson or anticholinergic may be helpful.
Domperidone can interact with following drugs:
• MAO inhibitors (phenelzine)
• HIV protease inhibitors (, indinavir)
• "azole" antifungals ( itraconazole, fluconazole, ketoconazole, miconazole)
• erythromycin antibiotics ( clarithromycin)
Always ask your doctor to decide how to combine those drugs together with domperidone.
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